Chondroitinase ABC reduces time to muscle reinnervation and improves functional recovery after sciatic nerve transection in rats

Chondroitinase ABC reduces time to muscle reinnervation and improves functional recovery after sciatic nerve transection in rats.

Application of chondroitinase ABC (ChABC) to injured peripheral nerves improves axon regeneration, but it is not known whether functional recovery is also improved. Recordings of EMG activity [soleus (Sol) M response and H reflexes] evoked by nerve stimulation and of Sol and tibialis anterior (TA) EMG activity and hindlimb and foot kinematics during slope walking were made to determine whether ...

Chondroitinase ABC reduces time to muscle reinnervation and improves functional 5 recovery after sciatic nerve transection in rats 6 7 8

46 Application of chondroitinase ABC (ChABC) to injured peripheral nerves improves axon 47 regeneration, but it is not known whether functional recovery is also improved. Recordings of 48 EMG activity (soleus (Sol) M-response and H-reflexes) evoked by nerve stimulation and of Sol 49 and tibialis anterior (TA) EMG activity and hindlimb and foot kinematics during slope walking 50 were made to det...

Muscle Differentiation after Sciatic Nerve Transection and Reinnervation in Adult Rats

Muscle differentiation after sciatic nerve transection and reinnervation in adult rats.

Reinnervation after peripheral nerve transections generally leads to poor functional recovery. In order to study whether changes in muscles might be a contributing factor in this phenomenon we studied muscle morphology and fibre type distributions after sciatic nerve transection in the rat hind limb. Proximally, before the bifurcation in the tibial and common peroneal nerve, a 12 mm segment of ...

Crocin Enhanced Functional Recovery after Sciatic Nerve Crush Injury in Rats

Objective(s): Crocin is a constituent of saffron and has many biological functions. The present study aimed to investigate the effects of intraperitoneal (IP) injection of crocin on sciatic nerve regeneration in male Wistar rats. Materials and Methods: Fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...